Synthesis of difluoromethyl carbinols from the Friedel–Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates-Reference-Cited by-同舟云学术

Synthesis of difluoromethyl carbinols from the Friedel–Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates

Published:2022 Issue:22 Volume:9 Page:6273-6280
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Cai Xiaojia¹,Xu Jinyuan¹,Cui Xueli¹,Qu Jing¹,Sun Weiqiang¹,Hu Jinhui¹,Zhao Shuwen¹,Chen Wen-Hua¹^ORCID,Li Hongliang²^ORCID,Wu Jia-Qiang¹^ORCID

Affiliation:

1. School of Biotechnology and Health Sciences, Wuyi University, 22 Dongchengcun, Jiangmen 529020, People's Republic of China

2. School of Medicine, Yunnan University, 2 Cuihu North Road, Kunming, 650091, People's Republic of China

Abstract

An efficient, sustainable and straightforward method is reported for the synthesis of a series of α,α-difluoromethyl carbinols via K2CO3-triggered Friedel–Crafts reaction of electron-rich arenes using the stable and easily affordable 2,2-difluorovinyl arylsulfonate.

Funder

Wuyi University

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01277D

Reference94 articles.

1. Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism