Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism-Reference-Cited by-同舟云学术

Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism

Published:2021-04-12 Issue:8 Volume:64 Page:4516-4531
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zafrani Yossi¹^ORCID,Parvari Galit²^ORCID,Amir Dafna¹,Ghindes-Azaria Lee¹,Elias Shlomi¹,Pevzner Alexander³,Fridkin Gil¹^ORCID,Berliner Anat¹,Gershonov Eytan¹,Eichen Yoav²^ORCID,Saphier Sigal¹^ORCID,Katalan Shahaf⁴

Affiliation:

1. Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

2. Schulich Faculty of Chemistry Technion, Israel Institute of Technology, Technion City, Haifa 3200008, Israel

3. Department of Physical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

4. Department of Pharmacology, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

Funder

Israeli Prime Minister’s office

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01868

Reference84 articles.

1. Understanding organofluorine chemistry. An introduction to the C–F bond

2. Introduction of Fluorine and Fluorine-Containing Functional Groups

3. Applications of Fluorine in Medicinal Chemistry

4. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

5. Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

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