Catalytic asymmetric synthesis of chiral thiohydantoins <i>via</i> the domino cyclization reaction of β,γ-unsaturated α-ketoesters and <i>N,N</i>′-dialkylthiourea-Reference-Cited by-同舟云学术

Catalytic asymmetric synthesis of chiral thiohydantoins via the domino cyclization reaction of β,γ-unsaturated α-ketoesters and N,N′-dialkylthiourea

Published:2022 Issue:16 Volume:9 Page:4358-4364
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Meng-Cheng¹,Wang Dong-Chao²^ORCID,Qu Gui-Rong²,Guo Hai-Ming¹²^ORCID

Affiliation:

1. School of Environment, Henan Normal University, Xinxiang, Henan Province 453007, China

2. NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China

Abstract

The first catalytic asymmetric route to synthesize chiral thiohydantoins using a chiral phosphoric acid-catalyzed domino cyclization reaction of N,N′-dialkyl thioureas with β,γ-unsaturated α-ketoesters.

Funder

National Natural Science Foundation of China

Henan University

Natural Science Foundation of Henan Province

Henan Key Laboratory of Organic Functional Molecules and Drug Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00669C

Reference75 articles.