The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε-Reference-Cited by-同舟云学术

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The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

Published:2018 Issue:28 Volume:16 Page:5097-5101
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Yin-He¹²³⁴⁵^ORCID,Di Bin¹²³⁴⁵^ORCID,Yang Da-Song¹²³⁴⁵^ORCID

Affiliation:

1. Jiang Su Key Laboratory of Drug Design and Optimization

2. Key Laboratory on Protein Chemistry and Structural Biology

3. China Pharmaceutical University

4. Nanjing 210009

5. China

Abstract

The first example of a counterintuitive freezing-induced peptide ligation was discovered during the total synthesis of human interferon-ε (187 amino acids) which blocks HIV infection through unique mechanisms.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01365A

Reference33 articles.

1. Origins of HIV and the AIDS Pandemic

2. HIV-AIDS: much accomplished, much to do

3. Viruses and Interferons

4. Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interferon Epsilon: Properties and Functions;Current Molecular Medicine;2024-06-07

2. Advances in Cryochemistry: Mechanisms, Reactions and Applications;Molecules;2021-02-01

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