Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection-Reference-Cited by-同舟云学术

Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection

Published:2013-03 Issue:6123 Volume:339 Page:1088-1092
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fung Ka Yee¹,Mangan Niamh E.¹,Cumming Helen¹,Horvat Jay C.²,Mayall Jemma R.²,Stifter Sebastian A.¹,De Weerd Nicole¹,Roisman Laila C.¹³,Rossjohn Jamie³,Robertson Sarah A.⁴,Schjenken John E.⁴,Parker Belinda⁵⁶,Gargett Caroline E.⁷⁸,Nguyen Hong P. T.⁷,Carr Daniel J.⁹,Hansbro Philip M.²,Hertzog Paul J.¹

Affiliation:

1. Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

2. Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia.

3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

4. Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia.

5. Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

6. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.

7. The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

8. Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

9. Department of Ophthalmology and Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Abstract

A Role for IFN-ɛ Type I interferons (IFNs) are critical cytokines involved in host defense against pathogens, particularly viruses. IFN-ɛ is an IFN-like gene encoded within the type I IFN locus in mice and humans whose function has not been characterized. Fung et al. (p. 1088 ) created mice with a genetic deletion in Ifn -ɛ and found that, like other type I IFNs, IFN-ɛ signals through the IFN-α receptors 1 and 2. However, unlike these other cytokines, which are primarily expressed by immune cells and are induced upon immune cell triggering, IFN-ɛ was expressed exclusively by epithelial cells of the female reproductive tract in both mice and humans and its expression was hormonally regulated. IFN-ɛ–deficient mice were more susceptible to infection with herpes simplex virus 2 and Chlamydia muridarum , two common sexually transmitted pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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