Synthesis of acyl fluorides through deoxyfluorination of carboxylic acids-Reference-Cited by-同舟云学术

Synthesis of acyl fluorides through deoxyfluorination of carboxylic acids

Published:2023 Issue:47 Volume:21 Page:9372-9378
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cen Mengjie¹,Yang Xi¹,Zhang Shanshan¹,Gan Liguang¹,Liu Long¹^ORCID,Chen Tieqiao¹^ORCID

Affiliation:

1. Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemical, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou, 570228, China

Abstract

A direct deoxyfluorination of carboxylic acids by utilizing KF as fluoride source has been developed. Scale-up reaction could be carried out under the solvent-free conditions, which exhibited the practicability of this reaction in organic synthesis.

Funder

National Natural Science Foundation of China

Key Research and Development Project of Hainan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01557B

Reference68 articles.

1. Fluorine in medicinal chemistry

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

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4. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

5. Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions

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