Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

Author:

Bonnefoy Clémence1ORCID,Gallego Adrien12,Delobel Clément1ORCID,Raynal Betty2ORCID,Decourt Maxime2ORCID,Chefdeville Emmanuel3ORCID,Hanquet Gilles4ORCID,Panossian Armen4ORCID,Leroux Frédéric R.4ORCID,Toulgoat Fabien12ORCID,Billard Thierry1ORCID

Affiliation:

1. Institute of Chemistry and Biochemistry (UMR CNRS 5246) CNRS Université Lyon 1, CPE Lyon 1 rue Victor Grignard 69622 Lyon France

2. CPE Lyon Campus LyonTech-La Doua 43 Bd du 11 novembre 1918 69616 Villeurbanne France

3. NMR Centre Université Lyon 1, CNRS 1 rue Victor Grignard 69622 Lyon France

4. Université de Strasbourg Université de Haute-Alsace CNRS, UMR 7042-LIMA, ECPM 67000 Strasbourg France

Abstract

AbstractAcyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl chlorides. This study delves into the properties and reactivity of acyl fluorides, particularly their reaction with amines and alcohols, to elucidate their distinct characteristics. We also introduce a facile and practical synthesis of acyl fluorides from a stable solution of CF3O salt. Additionally, we establish an efficient one‐pot process for the direct preparation of amides or esters from corresponding acids and amines or alcohols, showcasing the remarkable efficiency of acyl fluorides in these transformations.

Funder

Agence Nationale de la Recherche

Publisher

Wiley

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