Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives-Reference-Cited by-同舟云学术

Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives

Published:2017 Issue:6 Volume:8 Page:1235-1245
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Díaz José Luis¹²³^ORCID,Corbera Jordi¹²³,Cuberes Rosa¹²³,Contijoch Montserrat¹²³^ORCID,Enrech Raquel¹²³,Yeste Sandra¹²³^ORCID,Montero Ana¹²³^ORCID,Dordal Albert¹²³^ORCID,Monroy Xavier¹²³,Almansa Carmen¹²³^ORCID

Affiliation:

1. Drug Discovery and Preclinical Development, Esteve

2. 08028 Barcelona

3. Spain

Abstract

The 4-acylaminopyrazolo[3,4-d]pyrimidine 9a was identified as a highly selective σ₁R antagonist, showing as well substantial antinociceptive properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00077D

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