Enantio-conversion and -selectivity of racemic atenolol kinetic resolution using free Pseudomonas fluorescens lipase (Amano) conducted via transesterification reaction-Reference-Cited by-同舟云学术

Enantio-conversion and -selectivity of racemic atenolol kinetic resolution using free Pseudomonas fluorescens lipase (Amano) conducted via transesterification reaction

Published:2016 Issue:31 Volume:6 Page:26077-26085
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Agustian Joni¹²³⁴⁵,Kamaruddin Azlina Harun⁶⁷⁸⁹,Aboul-Enein Hassan Y.¹⁰¹¹¹²¹³

Affiliation:

1. Department of Chemical Engineering

2. Faculty of Engineering

3. Universitas Lampung

4. Bandar Lampung 35145

5. Indonesia

6. School of Chemical Engineering

7. Universiti Sains Malaysia

8. Penang

9. Malaysia

10. Pharmaceutical and Medicinal Chemistry Department

11. National Research Centre

12. Cairo

13. Egypt

Abstract

Effects of reaction parameters on kinetic resolution of racemic atenolol usingPseudomonas fluorescenslipase were investigatedviatransesterification for production of pharmacologically active eutomer (S)-atenolol with high enantiomeric purity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA01942K

Reference41 articles.

1. Synthesis and comparative skin permeability of atenolol and propranolol esters

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3. Enantioselective Synthesis ofβ-Blockersvia Hydrolytic Kinetic Resolution of Terminal Oxiranes by Using Bimetallic Chiral {{2,2′-[Cyclohexane-1,2-diylbis(nitrilomethylidyne)]bis[phenolato]}(2−)}cobalt ([Co(salen)])-Type Complexes

4. An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution

5. Synthesis and application of bimetallic chiral [Co(salen)]-type complexes: a new catalytic approach to synthesis of optically pure β-blockers via kinetic resolution of epichlorohydrin

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