Two-stage tuberculosis diagnostics: combining centrifugal microfluidics to detect TB infection and Inh and Rif resistance at the point of care with subsequent antibiotic resistance profiling by targeted NGS-Reference-Cited by-同舟云学术

Two-stage tuberculosis diagnostics: combining centrifugal microfluidics to detect TB infection and Inh and Rif resistance at the point of care with subsequent antibiotic resistance profiling by targeted NGS

Published:2024 Issue:1 Volume:24 Page:74-84
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Schlanderer Judith¹^ORCID,Hoffmann Harald²,Lüddecke Jan¹³,Golubov Andrey⁴,Grasse Wolfgang⁵,Kindler Elisabeth V.⁵,Kohl Thomas A.⁶^ORCID,Merker Matthias⁶,Metzger Christoph⁵,Mohr Vanessa⁶,Niemann Stefan⁶,Pilloni Claudia⁴,Plesnik Sara⁴,Raya Bijendra⁷,Shresta Bhawana⁷,Utpatel Christian⁶,Zengerle Roland¹³,Beutler Markus⁴,Paust Nils¹³^ORCID

Affiliation:

1. Hahn-Schickard, 79110 Freiburg, Germany

2. SYNLAB Gauting SYNLAB Human Genetics Munich, 82131 Gauting, Germany

3. Laboratory for MEMS Applications, IMTEK – Department of Microsystems Engineering, University of Freiburg, 79110 Freiburg, Germany

4. WHO supranational Tuberculosis Reference Laboratory, IML red, 82131 Gauting, Germany

5. gerbion GmbH & Co KG, 70806 Kornwestheim, Germany

6. Molecular and Experimental Mycobacteriology, Forschungszentrum Borstel, 23845 Borstel, Germany

7. German Nepal Tuberculosis Project (GENETUP), Nepal Anti-Tuberculosis Association (NATA), Kalimati, Nepal

Abstract

Two-stage tuberculosis diagnostics from a single sample.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00783A

Reference51 articles.

1. Global tuberculosis report 2022, World Health Organization , 2022

2. Stop TB Partnership sounds the alarm on the TB funding crisis as TB deaths increase for a second year in a row and TB incidence rises for the first time in 20 years, https://www.stoptb.org/news/stop-tb-partnership-sounds-alarm-tb-funding-crisis-tb-deaths-increase-second-year-row-and-tb , Stop TB Partnership , 22 February 2023

3. Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic, https://www.who.int/news/item/14-10-2021-tuberculosis-deaths-rise-for-the-first-time-in-more-than-a-decade-due-to-the-covid-19-pandemic , World Health Organization , 8 February 2023

4. Global tuberculosis cases increase for the first time in 20 years, https://www.theguardian.com/global-development/2022/oct/28/global-tuberculosis-tb-cases-increase , The Guardian , 28 October 2022

5. Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

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