Engineering protein polymers of ultrahigh molecular weight via supramolecular polymerization: towards mimicking the giant muscle protein titin-Reference-Cited by-同舟云学术

Engineering protein polymers of ultrahigh molecular weight via supramolecular polymerization: towards mimicking the giant muscle protein titin

Published:2019 Issue:40 Volume:10 Page:9277-9284
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Ruidi¹²³⁴⁵,Li Jiayu⁶⁷⁸⁹,Li Xiumei¹²³⁴⁵,Guo Jin⁶⁷⁸⁹,Liu Junqiu¹²³⁴⁵^ORCID,Li Hongbin⁶⁷⁸⁹^ORCID

Affiliation:

1. State Key Laboratory of Supramolecular Structure and Materials

2. College of Chemistry

3. Jilin University

4. Changchun 130012

5. P. R. China

6. Department of Chemistry

7. The University of British Columbia

8. Vancouver

9. Canada

Abstract

Utilizing protein fragment reconstitution of a small protein GB1, we developed an efficient, supramolecular polymerization strategy to engineer protein polymers with ultrahigh molecular weight that mimic the giant muscle protein titin.

Funder

Natural Sciences and Engineering Research Council of Canada

Changjiang Scholar Program of Chinese Ministry of Education

National Natural Science Foundation of China

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02128K

Reference40 articles.

1. Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

2. The molecular elasticity of the extracellular matrix protein tenascin

3. Molecular mechanistic origin of the toughness of natural adhesives, fibres and composites

4. Elastomeric proteins: biological roles, structures and mechanisms

5. Nanospring behaviour of ankyrin repeats

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