Classification of baseline toxicants for QSAR predictions to replace fish acute toxicity studies

Author:

Nendza Monika123ORCID,Müller Martin453,Wenzel Andrea453

Affiliation:

1. Analytical Laboratory AL-Luhnstedt

2. 24816 Luhnstedt

3. Germany

4. Fraunhofer Institute for Molecular Biology and Applied Ecology IME

5. 57392 Schmallenberg

Abstract

Classification of baseline and excess toxicants to replace 50% of fish acute toxicity testing with reliable QSAR predictions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Management, Monitoring, Policy and Law,Public Health, Environmental and Occupational Health,Environmental Chemistry,General Medicine

Reference46 articles.

1. European Commission , Regulation (EC) no 1907/2006 of the european parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, European Commission, Brussels, Belgium, 2006

2. European Commission , Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes, 2010

3. W. M. S. Russel and R. L.Burch, The principles of humane experimental technique, Methuen & Co Ltd, London, 1959

4. Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross‐sector approach

5. Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status

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