Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity

Author:

Juhng Seorin1,Song Jieun2,You Jeongyun1,Park Jihyun2,Yang Huisuk3,Jang Mingyu3,Kang Geonwoo3,Shin Jiwoo1,Ko Hyuk Wan2,Jung Hyungil13ORCID

Affiliation:

1. Department of Biotechnology, Building 123, Yonsei University, Seoul 03722, Korea

2. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea

3. Juvic Inc. 272 Digital-ro, Guro-gu, Seoul 03722, Korea

Abstract

The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery.

Funder

National Research Foundation of Korea

Korea Health Industry Development Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference46 articles.

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2. Physical inactivity, sedentary lifestyle and obesity in the European Union

3. Obesity: The Public Health Challenge of Our Time

4. Mechanisms linking obesity to insulin resistance and type 2 diabetes

5. Obesity and Cancer: Evidence, Impact, and Future Directions

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