Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: <i>in silico</i>, synthesis, and biological approach-Reference-Cited by-同舟云学术

Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach

Published:2023 Issue:12 Volume:14 Page:2768-2781
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pal Kavita¹,Lala Sahil²³^ORCID,Agarwal Priyanka²³,Patel Tarosh S.⁴^ORCID,Legac Jenny⁵,Rahman Md. Ataur⁶,Ahmedi Saiema⁷,Shahid Nida⁸,Singh Sneha⁹,Kumari Kajal⁹,Madhav Hari¹^ORCID,Sen Abhik⁹,Manzoor Nikhat⁷,Dixit Bharat C.⁴,Van Zyl Robyn²³,Rosenthal Philip J.⁵,Hoda Nasimul¹^ORCID

Affiliation:

1. Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India

2. Pharmacology Division, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of Witwatersrand, South Africa

3. Wits Institute for Research Malaria (WRIM), Faculty of Health Sciences, University of Witwatersrand, South Africa

4. Chemistry Department, V. P. & R. P. T. P Science College, Affiliated to Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India

5. Department of Medicine, University of California, San Francisco, CA, USA

6. Chemistry Program, New York University Abu Dhabi (NYUAD), Saadiyat Island, Abu Dhabi, United Arab Emirates

7. Medical Mycology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India

8. Department of Chemistry, Jamia Millia Islamia, New Delhi, India

9. Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Bihar, India

Abstract

Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as antimalarials and antileishmanial agents.

Funder

University Grants Commission

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00423F

Reference52 articles.

1. WHO team , World malaria report 2021 , Geneva, Switzerland , 2021

2. Malaria

3. Malaria

4. Antimalarial Drug Resistance: A Threat to Malaria Elimination

5. Artemisinin Action and Resistance in Plasmodium falciparum

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