The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry-Reference-Cited by-同舟云学术

The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry

Published:2020 Issue:11 Volume:37 Page:1511-1531
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Wu Zhi-Chen¹²³⁴⁵,Boger Dale L.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. The Skaggs Institute for Chemical Biology

3. The Scripps Research Institute

4. La Jolla

5. USA

Abstract

This review summarizes and highlights recent advances in medicinal chemistry of natural products enabled by total synthesis that provide “supernatural products” with improved properties superseding the natural products themselves.

Funder

National Cancer Institute

National Institute on Drug Abuse

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NP/D0NP00060D

Reference234 articles.

1. The Role of Natural Product Chemistry in Drug Discovery

2. Natural products: A continuing source of novel drug leads

3. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

4. Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

5. Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses

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