Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants-Reference-Cited by-同舟云学术

Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants

Published:2022 Issue:2 Volume:22 Page:326-342
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Eslami Amirabadi Hossein¹²^ORCID,Donkers Joanne M.¹^ORCID,Wierenga Esmée¹,Ingenhut Bastiaan³,Pieters Lisanne¹,Stevens Lianne¹⁴,Donkers Tim⁵,Westerhout Joost⁶,Masereeuw Rosalinde²^ORCID,Bobeldijk-Pastorova Ivana¹,Nooijen Irene¹,van de Steeg Evita¹

Affiliation:

1. Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, The Netherlands

2. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

3. Materials solution department, TNO, and Brightlands Materials Centre, Geleen, The Netherlands

4. Department of Surgery, Division of Transplantation, Leiden University Medical Centre, Leiden, The Netherlands

5. Division of Space systems engineering, TNO, Delft, the Netherlands

6. RAPID, TNO, Utrecht, the Netherlands

Abstract

The Intestinal Explant Barrier Chip (IEBC) mechanically fixes human and porcine intestinal tissue explants between an apical and basolateral microchannel and is the first microphysiological system to study intestinal drug absorption ex vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D1LC00669J

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