Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes

Author:

Edd Jon F.12345ORCID,Mishra Avanish12345,Dubash Taronish D.64574,Herrera Stefan12345ORCID,Mohammad Ridhwan12345,Williams E. Kendall12345,Hong Xin645,Mutlu Baris R.12345,Walsh John R.12345,Machado de Carvalho Fernanda645,Aldikacti Berent12345ORCID,Nieman Linda T.645,Stott Shannon L.12345,Kapur Ravi895,Maheswaran Shyamala64574,Haber Daniel A.64574,Toner Mehmet12345

Affiliation:

1. BioMEMS Resource Center

2. Center for Engineering in Medicine and Surgical Services

3. Massachusetts General Hospital and Harvard Medical School

4. Boston

5. USA

6. Cancer Center, Massachusetts General Hospital

7. Harvard Medical School

8. MicroMedicine, Inc.

9. Waltham

Abstract

Rare CTC clusters can be purified intact from large blood volumes with a continuous three-stage non-equilibrium inertial separation array (NISA).

Funder

American Cancer Society

National Institute of Biomedical Imaging and Bioengineering

Howard Hughes Medical Institute

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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