Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility-Reference-Cited by-同舟云学术

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

Published:2014-07-11 Issue:6193 Volume:345 Page:216-220
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yu Min¹²,Bardia Aditya¹³,Aceto Nicola¹,Bersani Francesca¹,Madden Marissa W.¹,Donaldson Maria C.¹,Desai Rushil¹,Zhu Huili¹,Comaills Valentine¹,Zheng Zongli¹⁴⁵,Wittner Ben S.¹,Stojanov Petar⁶,Brachtel Elena⁴,Sgroi Dennis¹⁴,Kapur Ravi⁷,Shioda Toshihiro¹³,Ting David T.¹³,Ramaswamy Sridhar¹³,Getz Gad¹⁴⁶,Iafrate A. John¹⁴,Benes Cyril¹³,Toner Mehmet⁷⁸,Maheswaran Shyamala¹⁸,Haber Daniel A.¹²³

Affiliation:

1. Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

2. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

3. Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

4. Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA.

5. Department of Medical Epidemiology and Biostatistics, Karolinska Insitutet, Stockholm, Sweden.

6. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

7. Center for Bioengineering in Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

8. Department of Surgery, Harvard Medical School, Charlestown, MA 02129, USA.

Abstract

Staying one step ahead of tumors Cancer treatments require continual adjustment. A drug that works initially will lose its potency as the tumor acquires new mutations that allow it to bypass the drug's lethal effects. To stay ahead of the tumor, oncologists need a noninvasive way to collect tumor cells from patients over the course of their treatment. Analyzing the mutations in these samples may help them choose the right drugs as the tumors change. In a small study of breast cancer patients, Yu et al. show that rare tumor cells circulating in the blood can be captured in viable form and used for this purpose. Science , this issue p. 216

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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