Design, synthesis and biological evaluation of light-driven on–off multitarget AChE and MAO-B inhibitors

Author:

Paolino Marco1ORCID,Rullo Mariagrazia2ORCID,Maramai Samuele1ORCID,de Candia Modesto2,Pisani Leonardo2ORCID,Catto Marco2,Mugnaini Claudia1,Brizzi Antonella1,Cappelli Andrea1ORCID,Olivucci Massimo13ORCID,Corelli Federico1ORCID,Altomare Cosimo D.2

Affiliation:

1. Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy

2. Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy

3. Chemistry Department, Bowling Green State University, USA

Abstract

We report a small library of cinnamic acid-inspired isomeric compounds with light-driven on–off multitarget activity against AChE and MAO-B, enzymatic targets related to Alzheimer's disease.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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