Design, synthesis and biological evaluation of light-driven on–off multitarget AChE and MAO-B inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of light-driven on–off multitarget AChE and MAO-B inhibitors

Published:2022 Issue:7 Volume:13 Page:873-883
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Paolino Marco¹^ORCID,Rullo Mariagrazia²^ORCID,Maramai Samuele¹^ORCID,de Candia Modesto²,Pisani Leonardo²^ORCID,Catto Marco²,Mugnaini Claudia¹,Brizzi Antonella¹,Cappelli Andrea¹^ORCID,Olivucci Massimo¹³^ORCID,Corelli Federico¹^ORCID,Altomare Cosimo D.²

Affiliation:

1. Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy

2. Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy

3. Chemistry Department, Bowling Green State University, USA

Abstract

We report a small library of cinnamic acid-inspired isomeric compounds with light-driven on–off multitarget activity against AChE and MAO-B, enzymatic targets related to Alzheimer's disease.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00042C

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