Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo

Author:

Mugnaini Claudia1ORCID,Brizzi Antonella1ORCID,Paolino Marco1,Scarselli Enrico1,Castelli Riccardo2ORCID,de Candia Modesto3ORCID,Gambacorta Nicola3,Nicolotti Orazio3ORCID,Kostrzewa Magdalena4,Kumar Poulami4,Mahmoud Ali Mokhtar4ORCID,Borgonetti Vittoria5,Iannotta Monica6,Morace Andrea6,Galeotti Nicoletta5,Maione Sabatino6,Altomare Cosimo D.3,Ligresti Alessia4ORCID,Corelli Federico1ORCID

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy

2. Department of Food and Drug, University of Parma, 43124 Parma, Italy

3. Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125 Bari, Italy

4. Institute of Biomolecular Chemistry, National Research Council of Italy, 80078 Pozzuoli, Naples ,Italy

5. Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50121 Florence, Italy

6. Department of Experimental Medicine, Division of Pharmacology, University of Campania “L. Vanvitelli″, 80138 Naples, Italy

Funder

Ministero dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Reference80 articles.

1. National Institute on Aging. Alzheimer’s Disease & Related Dementias. 2022. In https://www.nia.nih.gov/health/alzheimers.

2. Cholinesterase inhibitors as Alzheimer's therapeutics (Review)

3. WHO. Ageing and health, 2023. In https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.

4. Alzheimer disease

5. Advances in protein misfolding, amyloidosis and its correlation with human diseases

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