Synthesis of chiral polycyclic <i>N</i>-heterocycles <i>via</i> gold(<scp>i</scp>)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition-Reference-Cited by-同舟云学术

Synthesis of chiral polycyclic N-heterocycles via gold(i)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition

Published:2022 Issue:18 Volume:58 Page:3043-3046
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Han Xu¹²,Gaignard-Gaillard Quentin¹²,Retailleau Pascal¹,Gandon Vincent²³^ORCID,Voituriez Arnaud¹^ORCID

Affiliation:

1. Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France

2. Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, 91405, Orsay, France

3. Laboratoire de Chimie Moléculaire (LCM), CNRS UMR 9168, Ecole Polytechnique, Institut Polytechnique de Paris, route de Saclay, 91128 Palaiseau cedex, France

Abstract

A gold(i)-catalyzed synthesis of highly functionalized nitrogen-containing polycyclic scaffolds was developed (up to 92% yield and 93% ee).

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC06388J

Reference46 articles.

1. Gold-Catalyzed Cycloisomerizations of Enynes: A Mechanistic Perspective

2. Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity

3. Metal-catalyzed cycloisomerization as a powerful tool in the synthesis of complex sesquiterpenoids

4. Gold catalysis in total synthesis – recent achievements

5. Metal-catalyzed enyne cycloisomerization in natural product total synthesis

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