Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone <i>in vitro</i> and <i>in vivo</i>-Reference-Cited by-同舟云学术

Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo

Published:2022 Issue:12 Volume:3 Page:1380-1396
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Murakami Kazuma¹^ORCID,Sakaguchi Yoshiki¹,Taniwa Kota¹,Izuo Naotaka²,Hanaki Mizuho¹,Kawase Taiji³,Hirose Kenji³,Shimizu Takahiko²,Irie Kazuhiro¹^ORCID

Affiliation:

1. Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan

2. Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan

3. Nihon Waters, K.K., Tokyo, 140-0001, Japan

Abstract

We propose a site-specific inhibition of Aβ42 oligomerization by the green perilla-derived chalcone DDC, which is converted to its decomposed flavonoids (1–3) via nucleophilic aromatic substitution with water molecules, in vitro and in vivo.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00194B

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