Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids-Reference-Cited by-同舟云学术

Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids

Published:2024 Issue:8 Volume:15 Page:4233-4245
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Dong Qinchen¹²³,Cui Zhan¹²³^ORCID,Wu Xinming¹²³,Li Li⁴,Lu Fuping¹²³,Liu Fufeng¹²³^ORCID

Affiliation:

1. Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin, 300457, P. R. China

2. Tianjin Key Laboratory of Industrial Microbiology, Tianjin, 300457, P. R. China

3. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P. R. China

4. College of Sciences, Tianjin University of Science and Technology, Tianjin 300457, P. R. China

Abstract

Hesperetin was identified to be capable of inhibiting Aβ fibrillogenesis, disassembling mature fibrils, reducing the cytotoxicity and protecting C. elegans, and has good application prospects as a neuroprotective therapeutic agent for AD.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO05566C

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