Identification and development of pyrazolo[4,3-c]pyridine carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors-Reference-Cited by-同舟云学术

Identification and development of pyrazolo[4,3-c]pyridine carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors

Published:2017 Issue:1 Volume:41 Page:347-357
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Amaroju Suresh¹²³⁴,Kalaga Mahalakshmi Naidu¹²³⁴,Srinivasarao Singireddi¹²³⁴,Napiórkowska Agnieszka⁵⁶⁷⁸,Augustynowicz-Kopeć Ewa⁵⁶⁷⁸,Murugesan Sankaranarayanan⁹¹⁰¹¹¹²⁴,Chander Subhash⁹¹⁰¹¹¹²⁴,Krishnan Rangan¹²³⁴,Chandra Sekhar Kondapalli Venkata Gowri¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Birla Institute of Technology and Science-Pilani

3. R. R. Dist. Hyderabad

4. India

5. Microbiology Department

6. National Tuberculosis and Lung Diseases Research Institute

7. 01-138 Warsaw

8. Poland

9. Medicinal Chemistry Research Laboratory

10. Department of Pharmacy

11. Birla Institute of Technology & Science

12. Pilani

Abstract

A novel series of pyrazolo[4,3-c]pyridine carboxamides were synthesized and characterized. The compounds were evaluated for their antitubercular activity and pantothenate synthetase enzyme inhibition study.

Funder

Science for Equity, Empowerment and Development Division

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C6NJ02671K

Reference46 articles.

1. Recent advances in the design and synthesis of heterocycles as anti-tubercular agents

2. USPHS Tuberculosis Short-Course Chemotherapy Trial 21: Effectiveness, Toxicity, and Acceptability