Identification and development of pyrazolo[4,3-c]pyridine carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors

Author:

Amaroju Suresh1234,Kalaga Mahalakshmi Naidu1234,Srinivasarao Singireddi1234,Napiórkowska Agnieszka5678,Augustynowicz-Kopeć Ewa5678,Murugesan Sankaranarayanan91011124,Chander Subhash91011124,Krishnan Rangan1234,Chandra Sekhar Kondapalli Venkata Gowri1234ORCID

Affiliation:

1. Department of Chemistry

2. Birla Institute of Technology and Science-Pilani

3. R. R. Dist. Hyderabad

4. India

5. Microbiology Department

6. National Tuberculosis and Lung Diseases Research Institute

7. 01-138 Warsaw

8. Poland

9. Medicinal Chemistry Research Laboratory

10. Department of Pharmacy

11. Birla Institute of Technology & Science

12. Pilani

Abstract

A novel series of pyrazolo[4,3-c]pyridine carboxamides were synthesized and characterized. The compounds were evaluated for their antitubercular activity and pantothenate synthetase enzyme inhibition study.

Funder

Science for Equity, Empowerment and Development Division

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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