Affiliation:
1. Department of Pharmaceutical Sciences, Sanskriti University, Chhata, Mathura, Uttar Pradesh, India
Abstract
Abstract:
Pyrazole is considered an important active scaffold that possesses various types of pharmacological
activities. The overwhelming literature reported earlier reflects the immense biological
potential of pyrazole derivatives. The presence of this moiety in various FDA-approved drugs,
including celecoxib (anti-inflammatory), apixaban (anticoagulant), rimonabant (anti-obesity), difenamizole
(analgesic), and sildenafil (for erectile dysfunction), has proved its pharmacological potential.
Owing to its diversity in the biological field, this nucleus has attracted the attention of
many researchers to study its skeleton chemically and biologically. This review highlights the literature
supporting the research of the past 10 years related to the structures of pyrazole derivatives
with their corresponding biological activities. The findings of this review may open new avenues
for an upcoming scientific breakthrough.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
8 articles.
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