Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy-Reference-Cited by-同舟云学术

Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

Published:2020 Issue:5 Volume:11 Page:1316-1334
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Testolin Giambattista¹²³⁴,Cirnski Katarina⁵⁶⁴⁷⁸,Rox Katharina¹²³⁴⁵,Prochnow Hans¹²³⁴,Fetz Verena¹²³⁴,Grandclaudon Charlotte¹²³⁴⁵,Mollner Tim¹²³⁴^ORCID,Baiyoumy Alain¹²³⁴,Ritter Antje¹²³⁴,Leitner Christian¹²³⁴⁵,Krull Jana¹²³⁴,van den Heuvel Joop⁹²³⁴,Vassort Aurelie¹⁰¹¹¹²,Sordello Sylvie¹⁰¹³¹⁴,Hamed Mostafa M.⁷⁸⁴,Elgaher Walid A. M.⁷⁸⁴^ORCID,Herrmann Jennifer⁵⁶⁴⁷⁸,Hartmann Rolf W.⁷⁸⁴,Müller Rolf⁵⁶⁴⁷⁸,Brönstrup Mark¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemical Biology

2. Helmholtz Centre for Infection Research

3. 38124 Braunschweig

4. Germany

5. German Center for Infection Research (DZIF)

6. Site Hannover-Braunschweig

7. Helmholtz Institute for Pharmaceutical Research Saarland

8. 66123 Saarbrücken

9. Group Recombinant Protein Expression

10. Evotec ID

11. 69289 Marcy l'Etoile

12. France

13. Cheshire SK10 4TG

14. UK

Abstract

Structure–activity relationship studies of the natural product cystobactamid at four different positions led to novel imaging probes and analogs with superior antibacterial activities and in vivo efficacy.

Funder

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Infektionsforschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04769G

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