Chemoselective ratiometric imaging of protein S-sulfenylation
Author:
Affiliation:
1. Department of Chemistry and Program in Chemical Biology
2. University of Michigan
3. Ann Arbor
4. USA
5. Department of Biophysics
6. Department of Pharmacology and Department of Psychiatry
7. University of Michigan Medical School
Abstract
Here we report a ratiometric fluorescent probe for chemoselective conjugation to sulfenic acids in living cells.
Funder
National Institute of General Medical Sciences
American Cancer Society
National Institute of Biomedical Imaging and Bioengineering
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC02285A
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1. Roles for the Two Cysteine Residues of AhpC in Catalysis of Peroxide Reduction by Alkyl Hydroperoxide Reductase from Salmonella typhimurium
2. Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
3. Biological chemistry and functionality of protein sulfenic acids and related thiol modifications
4. Synthesis of Chemical Probes to Map Sulfenic Acid Modifications on Proteins
5. A chemical approach for detecting sulfenic acid-modified proteins in living cells
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