A scalable filtration method for high throughput screening based on cell deformability-Reference-Cited by-同舟云学术

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A scalable filtration method for high throughput screening based on cell deformability

Published:2019 Issue:2 Volume:19 Page:343-357
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Gill Navjot Kaur¹²³⁴^ORCID,Ly Chau⁵²³⁴,Nyberg Kendra D.¹²³⁴^ORCID,Lee Linus¹²³⁴,Qi Dongping¹²³⁴^ORCID,Tofig Bobby⁶⁷²³⁴,Reis-Sobreiro Mariana⁸⁹³⁴^ORCID,Dorigo Oliver¹⁰¹¹¹²¹³⁴,Rao JianYu¹⁴²³⁴,Wiedemeyer Ruprecht¹⁵⁹³⁴,Karlan Beth¹⁵⁹³⁴,Lawrenson Kate¹⁵⁹³⁴,Freeman Michael R.⁸⁹³⁴,Damoiseaux Robert⁶⁷²³⁴,Rowat Amy C.¹²³⁴^ORCID

Affiliation:

1. Department of Integrative Biology and Physiology

2. University of California Los Angeles

3. Los Angeles

4. USA

5. Department of Bioengineering

6. Molecular Screening Shared Resource

7. California NanoSystems Institute

8. Department of Surgery and Biomedical Sciences

9. Cedars-Sinai Medical Center

10. Department of Obstetrics and Gynecology

11. Stanford Cancer institute

12. Stanford University

13. Stanford

14. Department of Pathology and Laboratory Medicine

15. Samuel Oschin Comprehensive Cancer Institute

Abstract

We demonstrate a scalable, high throughput method to screen cells based on their ability to deform through micron-scale gaps.

Funder

National Science Foundation

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C8LC00922H

Reference126 articles.

1. Cell-Based Assays for High-Throughput Screening

2. Cell-based high-throughput screens for the discovery of chemotherapeutic agents

3. Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests

4. Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System

5. Development of a Cell-Based, High-Throughput Screening Assay for ATM Kinase Inhibitors

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