Acoustic impedance-based size-independent isolation of circulating tumour cells from blood using acoustophoresis

Abstract

Here, we report a label-free method based on acoustic impedance contrast for the isolation of CTCs from peripheral blood mononuclear cells (PBMCs) in a microchannel using acoustophoresis. Applying this method, we demonstrate the label-free isolation of HeLa and MDA-MB-231 cells from PBMCs.