Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors-Reference-Cited by-同舟云学术

Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors

Published:2023 Issue:10 Volume:59 Page:1373-1376
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Spennacchio Mauro¹,Colella Marco¹^ORCID,Andresini Michael¹,Dibenedetto Roberta Savina¹,Graziano Elena¹,Aramini Andrea²,Degennaro Leonardo¹,Luisi Renzo¹^ORCID

Affiliation:

1. Flow Chemistry and Microreactor Technology FLAME-Lab, Department of Pharmacy – Drug Sciences, University of Bari “A. Moro”, Bari, 70125, Italy

2. Department of Discovery, Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila, 67100, Italy

Abstract

A direct nucleophilic monofluoroalkylation strategy leveraging on lithium fluorocarbenoids has been developed.

Funder

Ministero dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D2CC06717J

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