One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3,5-dicarbonitriles enabling anti-cancer bioactivity-Reference-Cited by-同舟云学术

One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3,5-dicarbonitriles enabling anti-cancer bioactivity

Published:2022 Issue:37 Volume:12 Page:23889-23897
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Nicely Lynden G.¹,Vala Ruturajsinh M.²^ORCID,Upadhyay Dipti B.²,Nogales Joaquina¹,Chi Celestine³,Banerjee Sourav¹^ORCID,Patel Hitendra M.²^ORCID

Affiliation:

1. Department of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK

2. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat, India

3. Department of Medical Biochemistry and Microbiology, Uppsala University, SE-75123 Uppsala, Sweden

Abstract

The one-pot synthetic strategy of amino-pyridones with potent anti-cancer activity against breast, brain, liver, and lung cancer cells either alone or in combination with clinically relevant receptor tyrosine kinase and proteasome inhibitors.

Funder

Cancer Research UK

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03579K

Reference26 articles.

1. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

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3. Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

4. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

5. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

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