Biophysical investigation into the antibacterial action of modelin-5-NH2

Author:

Dennison Sarah R.1234ORCID,Hauß Thomas5678ORCID,Badiani Kamal9104,Harris Frederick11234,Phoenix David A.1213144ORCID

Affiliation:

1. School of Pharmacy and Biological Sciences

2. University of Central Lancashire

3. Preston PR1 2HE

4. UK

5. Macromolecular Crystallography

6. Helmholtz-Zentrum Berlin für Materialien und Energie

7. Berlin

8. Germany

9. Pepceuticals Limited

10. Enderby

11. School of Forensic and Investigative Science

12. Office of the Vice Chancellor

13. London South Bank University

14. London SE1 0AA

Abstract

Neutron diffraction studies showed that modelin-5-CONH2has potent antibacterial activity which involves membrane interactive, tilted α-helical structure.

Funder

Seventh Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Reference69 articles.

1. Antibiotic resistance

2. World Health Organization, Antimicrobial resistance: global report on surveillance 2014, Geneva, Switzerland, 2014

3. World Health Organisation, Global action plan on antimicrobial drug resistance, Geneva, Switzerland, 2015

4. J. O'Neill , Tackling drug-resistant infections globally: final report and recommendations , 2016

5. World Health Organisation, Global Priority List of Antibiotic-resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics, Geneva, Switzerland, 2017

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