Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Author:

Xia Chen-Xi12,Gao Alex Xiong12,Zhu Yue3,Dong Tina Ting-Xia12,Tsim Karl Wah-Keung12ORCID

Affiliation:

1. Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, 518000, China

2. Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China

3. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China

Abstract

Seabuckthorn flavonoids mitigated depressive behaviors, improved biochemical indexes and modulated the gut microbiota of CUMS-induced mice.

Funder

Guangdong Provincial Applied Science and Technology Research and Development Program

Guangzhou Science, Technology and Innovation Commission

Foshan Science and Technology Bureau

Research Grants Council, University Grants Committee

Innovation and Technology Commission - Hong Kong

Shenzhen Science and Technology Innovation Program

Zhongshan Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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