Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides-Reference-Cited by-同舟云学术

Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides

Published:2020 Issue:18 Volume:56 Page:2799-2802
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hu Die¹²³^ORCID,Zong Xun-Cheng⁴⁵⁶⁷²,Xue Feng⁸⁹¹⁰³,Li Chuang⁴⁵⁶⁷²,Hu Bo-Chun⁴⁵⁶⁷²^ORCID,Wu Min-Chen¹²³^ORCID

Affiliation:

1. Wuxi School of Medicine, Jiangnan University

2. Wuxi

3. China

4. Key Laboratory of Carbohydrate Chemistry and Biotechnology

5. Ministry of Education

6. School of Biotechnology

7. Jiangnan University

8. School of Marine and Bioengineering

9. Yancheng Institute of Technology

10. Yancheng 224051

Abstract

Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC00283F

Reference38 articles.

1. Application of hydrolytic kinetic resolution (HKR) in the synthesis of bioactive compounds

2. Mechanistic Basis for High Stereoselectivity and Broad Substrate Scope in the (salen)Co(III)-Catalyzed Hydrolytic Kinetic Resolution

3. Probing Competitive Enantioselective Approach Vectors Operating in the Jacobsen−Katsuki Epoxidation: A Kinetic Study of Methyl-Substituted Styrenes

4. Synthetic applications of epoxide hydrolases

5. Epoxide Hydrolases and their Application in Organic Synthesis

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