The quasi-irreversible inactivation of cytochrome P450 enzymes by paroxetine: a computational approach
Author:
Affiliation:
1. Chemistry Department
2. Faculty of Science
3. Beni-Suef University
4. Beni-Suef
5. Egypt
6. Departamento de Química
7. Universidad Autónoma de Madrid
8. Madrid
9. Spain
10. Institute for Advanced Research in Chemical Sciences (IAdChem)
Abstract
The potency of paroxetine as a P450 inhibitor is mainly attributed to the availability of two active sites on its structure, its compatibility with P450's active site and the ease of its tight coordination to heme iron.
Funder
Universidad Autónoma de Madrid
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00529K
Reference72 articles.
1. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
2. Heme-Containing Oxygenases
3. Metabolism of polyhalogenated compounds by a genetically engineered bacterium
4. Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast
5. M. A. Correia and P. R. O.de Montellano , in Cytochrome P450 , Springer , 2005 , pp. 247–322
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