Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide-Reference-Cited by-同舟云学术

Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide

Published:2016 Issue:3 Volume:7 Page:1738-1752
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Chairatana Phoom¹²³^ORCID,Chu Hiutung⁴⁵⁶,Castillo Patricia A.⁴⁵⁶,Shen Bo⁷⁸⁹,Bevins Charles L.⁴⁵⁶^ORCID,Nolan Elizabeth M.¹²³

Affiliation:

1. Department of Chemistry

2. Massachusetts Institute of Technology

3. Cambridge, USA

4. Department of Microbiology and Immunology

5. University of California Davis School of Medicine

6. Davis, USA

7. Department of General Internal Medicine and Gastroenterology and Hepatology

8. The Cleveland Clinic Foundation

9. Cleveland, USA

Abstract

Human α-defensin 6 (HD6) is a unique peptide of the defensin family that provides innate immunity in the intestine by self-assembling to form higher-order oligomers that entrap bacteria and prevent host cell invasion.

Funder

NIH Office of the Director

National Science Foundation

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04194E

Reference54 articles.

1. Intestinal mucosal barrier function in health and disease

2. Defensins in innate immunity

3. Paneth cells and innate mucosal immunity

4. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

5. Paneth Cells: Maestros of the Small Intestinal Crypts

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