Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity-Reference-Cited by-同舟云学术

Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity

Published:2024-01 Issue:4-6 Volume:45 Page:493-507
ISSN:1863-2297
Container-title:Seminars in Immunopathology
language:en
Short-container-title:Semin Immunopathol

Author:

Zhang Zhongwei,Tanaka Izumi,Nakahashi-Ouchida Rika,Ernst Peter B.,Kiyono Hiroshi,Kurashima Yosuke^ORCID

Abstract

AbstractGlycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s00281-023-00999-z.pdf

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1. Correction: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity;Seminars in Immunopathology;2024-01