Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo-Reference-Cited by-同舟云学术

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Published:2015 Issue:4 Volume:4 Page:1098-1114
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Jirkovská-Vávrová Anna¹²³⁴,Roh Jaroslav¹²³⁴,Lenčová-Popelová Olga¹⁵⁶⁴,Jirkovský Eduard¹⁵⁶⁴,Hrušková Kateřina¹²³⁴,Potůčková-Macková Eliška¹²³⁴,Jansová Hana¹²³⁴,Hašková Pavlína¹²³⁴,Martinková Pavla¹²³⁴,Eisner Tomáš¹²³⁴,Kratochvíl Marek¹²³⁴,Šůs Jan¹²³⁴,Macháček Miloslav¹²³⁴,Vostatková-Tichotová Lucie¹²³⁴,Geršl Vladimír¹⁵⁶⁴,Kalinowski Danuta S.⁷⁸⁹¹⁰¹¹,Muller Mark T.¹²¹³¹⁴¹⁵¹⁶,Richardson Des R.⁷⁸⁹¹⁰¹¹,Vávrová Kateřina¹²³⁴,Štěrba Martin¹⁵⁶⁴,Šimůnek Tomáš¹²³⁴

Affiliation:

1. Charles University in Prague

2. Faculty of Pharmacy in Hradec Králové

3. 500 05 Hradec Králové

4. Czech Republic

5. Faculty of Medicine in Hradec Králové

6. 500 38 Hradec Králové

7. Molecular Pharmacology and Pathology Program

8. Bosch Institute and Department of Pathology

9. University of Sydney

10. Sydney

11. Australia

12. College of Medicine

13. Biomedical Research

14. University of Central Florida

15. Orlando

16. U.S.A

Abstract

Topoisomerase II beta, rather than (or along with) iron chelation, may be a promising target for cardioprotection.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00048C

Reference67 articles.

1. L. Brunton , B.Chabner and B.Knollman, Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition, McGraw-Hill Professional, 2010

2. M. S. Ewer and E. T. H.Yeh, Cancer and the Heart, BC Decker, U.S.A., Hamilton, 2006

3. Clinical heart failure in a cohort of children treated with anthracyclines: A long-term follow-up study

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