Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions-Reference-Cited by-同舟云学术

Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Published:2021-03-22 Issue:7 Volume:64 Page:3997-4019
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jirkovská Anna¹,Karabanovich Galina¹,Kubeš Jan¹,Skalická Veronika¹,Melnikova Iuliia¹,Korábečný Jan²³,Kučera Tomáš³^ORCID,Jirkovský Eduard¹,Nováková Lucie¹,Bavlovič Piskáčková Hana¹,Škoda Josef¹,Štěrba Martin⁴,Austin Caroline A.⁵,Šimůnek Tomáš¹,Roh Jaroslav¹^ORCID

Affiliation:

1. Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

2. Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Králové, Czech Republic

3. Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 50005 Hradec Králové, Czech Republic

4. Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, 50003 Hradec Králové, Czech Republic

5. Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom

Funder

European Regional Development Fund

Grantov? Agentura Cesk? Republiky

Grantov? Agentura, Univerzita Karlova

University Hospital Hradec Kralove

Faculty of Military Health Sciences, University of Defence

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02157

Reference76 articles.

1. Creighton, A. M. Bis diketopiperazines. US3,941,790, 1976.

2. Antitumour Activity in a Series of bisDiketopiperazines

3. The effects of ICRF-154 in combination with other anticancer agents in vitro

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