Exploration of HIV-1 fusion peptide–antibody VRC34.01 binding reveals fundamental neutralization sites-Reference-Cited by-同舟云学术

Exploration of HIV-1 fusion peptide–antibody VRC34.01 binding reveals fundamental neutralization sites

Published:2019 Issue:34 Volume:21 Page:18569-18576
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Feng Mei¹²³⁴⁵,Bell David R.⁶⁷⁸⁹^ORCID,Kang Hongsuk⁶⁷⁸⁹,Shao Qiwen¹⁰¹¹¹²⁵,Zhou Ruhong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Physics

2. Institute of Quantitative Biology

3. Zhejiang University

4. Hangzhou

5. China

6. Computational Biological Center

7. IBM Thomas J. Watson Research Center

8. Yorktown Heights

9. USA

10. College of Nano Science and Technology

11. Soochow University

12. Suzhou 215123

Abstract

VRC34.01 antibody binding to a vulnerable site of HIV envelope glycoprotein (Env), the gp41 fusion peptide, renders robust HIV neutralization, but several critical mutations decrease binding affinity and result in unbinding.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP02909E

Reference50 articles.

1. HIV-1 Membrane Fusion

2. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

3. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

4. Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

5. Antibody responses to envelope glycoproteins in HIV-1 infection

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