HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen-Reference-Cited by-同舟云学术

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Published:2016-03-25 Issue:6280 Volume:351 Page:1458-1463
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jardine Joseph G.¹²³,Kulp Daniel W.¹²³,Havenar-Daughton Colin³⁴,Sarkar Anita²³⁵,Briney Bryan¹²³,Sok Devin¹²³,Sesterhenn Fabian¹,Ereño-Orbea June⁶,Kalyuzhniy Oleksandr¹²³,Deresa Isaiah³⁴,Hu Xiaozhen¹³,Spencer Skye¹³,Jones Meaghan¹³,Georgeson Erik¹³,Adachi Yumiko¹²³,Kubitz Michael¹²³,deCamp Allan C.⁷,Julien Jean-Philippe²³⁵⁶⁸,Wilson Ian A.²³⁵⁹,Burton Dennis R.¹²³¹⁰,Crotty Shane³⁴¹¹,Schief William R.¹²³¹⁰

Affiliation:

1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

5. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

6. Program in Molecular Structure and Function, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.

7. Vaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

8. Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

10. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.

11. Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.

Abstract

Baby steps toward bNAbs Some HIV-infected individuals develop heavily mutated, broadly neutralizing antibodies (bNAbs) that target HIV. Scientists aim to design vaccines that would elicit such antibodies. Jardine et al. report an important step toward this goal: They engineered an immunogen that could engage B cells from HIV-uninfected individuals that express the germline versions of the immunoglobulin genes harbored by a particular class of bNAbs. The frequencies of these B cells, their affinities for the immunogen, and structural analysis suggest that the immunogen is a promising candidate. Further shaping of the B cell response with subsequent immunogens may eventually elicit bNAbs in people. Science , this issue p. 1458

Funder

International AIDS Vaccine Initiative Neutralizing Antibody Consortium and Center

IAVI NAC Center

CAVD Vaccine Immunology Statistical Center (VISC)

Ragon Institute of MGH

Ragon Institute of MIT

Ragon Institute of Harvard

Bayer Science and Education Foundation

Helen Hay Whitney Foundation

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

CHAVI-ID