Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase
Author:
Affiliation:
1. Institut für Pharmazeutische Biologie und Biotechnologie
2. Philipps-Universität Marburg
3. 35037 Marburg
4. Germany
5. Interfakultäres Institut für Biochemie
6. Eberhard Karls Universität Tübingen
7. Tübingen 72076
Abstract
Structure-guided molecular modelling and site-directed mutagenesis of the tryptophan dimethylallyl transferase FgaPT2 led to creation of mutants with strongly enhanced activities towards geranyl and farnesyl diphosphates.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02037J
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