A regioselective, convergent, and additive-free approach for the synthesis of pyrido[1,4]oxazocines-Reference-Cited by-同舟云学术

A regioselective, convergent, and additive-free approach for the synthesis of pyrido[1,4]oxazocines

Published:2023 Issue:39 Volume:47 Page:18193-18198
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Tian Kai-Qiang¹,Zhang Tongbo²,Zhang Shi-Jiao³,Zhao Jun¹,Mao Leilei⁴,Duan Guiyun¹,Li Hong-Shuang¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, P. R. China

2. Beijing Pharmaceutical Research Institute, Heilongjiang ZBD Pharmaceutical Co., Ltd., Beijing 101102, P. R. China

3. Pharmacy Intravenous Admixture Services, The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, P. R. China

4. Institute for Neurological Research, The Second Affiliated Hospital; School of Basic Medical Sciences of Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, P. R. China

Abstract

The synthesis of pyrido[1,4]oxazocines from 4-Cl- and 2-Cl-substituted 3-(oxiran-2-yl)pyridines and ethanolamines was developed under additive-free conditions in a regioselective and convergent manner.

Funder

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ03776B

Reference26 articles.

1. Nefopam, a Nonsedative Benzoxazocine Analgesic, Selectively Reduces the Shivering Threshold in Unanesthetized Subjects

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3. Synthesis of 8-azaprotosappanin A derivatives via intramolecular palladium-catalyzed ortho C–H activation/C–C cyclization and their antibacterial activity

4. Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents

5. A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity