Synthesis of novel unnatural α-amino acids (UAAs) containing 7-hydroxy-2,2-dimethyl-chroman using isoxazole as a linker-Reference-Cited by-同舟云学术

Synthesis of novel unnatural α-amino acids (UAAs) containing 7-hydroxy-2,2-dimethyl-chroman using isoxazole as a linker

Published:2021 Issue:37 Volume:45 Page:17143-17148
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Raghavulu K.¹²,Gudipati Ramakrishna¹,Basavaiah K.²^ORCID,Rumalla Chidananda Swamy¹,Yennam Satyanarayana¹^ORCID,Behera Manoranjan¹^ORCID

Affiliation:

1. Chemistry Services, Aragen Life Sciences (Formerly known as GVK Biosciences), Plot No. 125 (part)&126, IDA, Mallapur, Hyderabad, Telangana, 500076, India

2. Department of Inorganic & Analytical Chemistry, Andhra University, Waltair Junction, Visakhapatnam, Andhra Pradesh, 530003, India

Abstract

An efficient and novel method for the preparation of unnatural α-amino acids (UAAs) containing 7-hydroxy-2,2-dimethyl-chroman via a 1,3-di-polar-cyloaddition reaction has been described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ01985F

Reference50 articles.

1. Diastereoselective Synthesis of Unnatural Amino Acids by Alkylation of α-tert-Butanesulfinamide Auxiliary-Bound Enolates

2. 2.6 Chiral Pool Synthesis: From α-Amino Acids and Derivatives

3. Amino acidic scaffolds bearing unnatural side chains: An old idea generates new and versatile tools for the life sciences

4. The Future of Peptide-based Drugs

5. Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction

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