Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction

Author:

Scott William L.1,Alsina Jordi1,Audu Christopher O.1,Babaev Evgenii1,Cook Linda1,Dage Jeffery L.1,Goodwin Lawrence A.1,Martynow Jacek G.1,Matosiuk Dariusz1,Royo Miriam1,Smith Judith G.1,Strong Andrew T.1,Wickizer Kirk1,Woerly Eric M.1,Zhou Ziniu1,O’Donnell Martin J.1

Affiliation:

1. Department of Chemistry and Chemical Biology, Indiana University−Purdue University, Indianapolis, Indiana 46202-3274, Department of Chemistry, Moscow State University, Moscow, Russia, Medicinal Analytical Chemistry, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University, Staszica 6, 20-081 Lublin, Poland, and Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1,...

Publisher

American Chemical Society (ACS)

Subject

General Chemistry

Reference183 articles.

1. Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases

2. Distributed Drug Discovery, Part 3: Using D3 Methodology to Synthesize Analogs of an Anti-Melanoma Compound

3. Search strategy: nitrogen-carbon-carbonyl substructure contained in 103 of the 365 structures in Tables 1−10 in ref4i.

4. For an excellent series of structurally-based comprehensive reviews on combinatorial library syntheses, see:

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