BIM-46174 fragments as potential ligands of G proteins
Author:
Affiliation:
1. Pharmaceutical Institute
2. Pharmaceutical Chemistry I
3. University of Bonn
4. 53121 Bonn
5. Germany
6. Molecular, Cellular and Pharmacobiology Section
7. Institute for Pharmaceutical Biology
8. 53115 Bonn
9. Institute of Inorganic Chemistry
Abstract
Fragments of BIM-46174 were synthesized and investigated as Gαq inhibitors.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00269C
Reference46 articles.
1. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry
2. Potent and Selective Peptide-based Inhibition of the G Protein Gαq
3. Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics
4. Gaq proteins: molecular pharmacology and therapeutic potential
5. Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule
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