Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process

Author:

Peng Fu12345,Zhao Qian6789,Huang Wei6789ORCID,Liu Shuai-Jiang6789,Zhong Ya-Jun6789,Mao Qing6789,Zhang Nan12345,He Gu12345ORCID,Han Bo6789ORCID

Affiliation:

1. State Key Laboratory of Biotherapy

2. West China Hospital

3. West China School of Pharmacy

4. Sichuan University

5. Chengdu 610041

6. State Key Laboratory of Southwestern Chinese Medicine Resources

7. Chengdu University of Traditional Chinese Medicine

8. Chengdu 611137

9. China

Abstract

A novel strategy for the synthesis of CF3-containing multi-substituted benzenes with high chemo- and regioselectivities under metal-free and air-tolerant conditions was established.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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