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Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

  • Published:2017 Issue:1 Volume:6 Page:81-88
  • ISSN:2045-452X
  • Container-title:Toxicology Research
  • language:en
  • Short-container-title:Toxicol. Res.

Author:

Akingbasote James A.1234,Foster Alison J.564,Jones Huw B.564,David Rhiannon564,Gooderham Nigel J.7891011,Wilson Ian D.7891011,Kenna J. Gerry12134

Affiliation:

1. MRC Centre for Drug Safety Science

2. University of Liverpool

3. Liverpool

4. UK

5. Drug Safety and Metabolism

6. Cambridge

7. Section of Computational and Systems Medicine

8. Department of Surgery and Cancer Faculty of Medicine

9. Imperial College London

10. London

11. SW7 2AZ UK

12. Drug Safety Consultant

13. Macclesfield

Abstract

HRN™ mice are valuable for P450-related hepatic drug biotransformation assessment, but not drug toxicity due to underlying liver histopathology.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

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