The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
Author:
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
http://link.springer.com/article/10.1007/s00204-018-2274-0/fulltext.html
Reference24 articles.
1. Akingbasote JA, Foster AJ, Jones HB, David R, Gooderham NJ, Wilson ID et al (2017) Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid. Toxicol Res 6:81–88
2. Alcock S (1970) An anti-inflammatory compound: non-toxic to animals but with an adverse action in man. Proc Eur Soc Study Drug Toxic 12:7
3. Chalmers TM, Kellgren JH, Platt DS (1969a) Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. II. Clinical trial in patients with rheumatoid arthritis. Ann Rheum Dis 28:595–601
4. Chalmers TM, Pohl JE, Platt DS (1969b) Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis. Ann Rheum Dis 28:590–594
5. Darnell M, Weidolf L (2013) Metabolism of xenobiotic carboxylic acids: focus on coenzyme A conjugation, reactivity, and interference with lipid metabolism. Chem Res Toxicol 26:1139–1155
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