A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines
Author:
Affiliation:
1. Department of Chemistry
2. UCL
3. London
4. UK
5. Department of Biochemical Engineering
6. Almac
7. Department of Biocatalysis & Isotope Chemistry
8. 20 Seagoe Industrial Estate
9. Craigavon
Abstract
A metagenomics mining strategy was used to identify new transaminases that were utilised in the synthesis of allylic amines.
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Pollution,Environmental Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/GC/C6GC02769E
Reference40 articles.
1. High-Yield Biocatalytic Amination Reactions in Organic Synthesis
2. ω-Transaminases for the synthesis of non-racemic α-chiral primary amines
3. Features and technical applications of ω-transaminases
4. ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids
5. The Industrial Age of Biocatalytic Transamination
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